Highlights
- •The occurrence of PSE was significantly correlated with NLR levels.
- •After adjusting for potential confounders, high NLR was independently associated with an increased risk of PSE.
- •NLR levels were independently associated with the occurrence of PSE in the poor functional outcome group, while this association was not significant in the favorable functional outcome group.
- •The model (cortical involvement + hematoma volume + early seizures + NLR) showed good prognostic performance.
Abstract
Background
Post-stroke epilepsy (PSE) is one of the major sequelae of stroke. Inflammation has
been implicated in the development of stroke. The study aimed to explore the relationship
between neutrophil-to-lymphocyte ratio (NLR) levels and epilepsy in patients with
primary intracerebral hemorrhage (ICH).
Methods
A retrospective study was performed on 1132 patients with first-time ICH. Blood samples
were obtained at admission after ICH. Patients included in the study were classified
into three groups according to NLR tertiles. Logistic regression was used to analyze
the relationship between NLR levels and the occurrence of PSE.
Results
The occurrence of PSE was significantly correlated with NLR levels (r = 0.118, P < 0.001). Patients with PSE had higher NLR levels than those without PSE. After adjusting
for potential confounders, high NLR was independently associated with an increased
risk of PSE (OR = 1.861, 95% CI 1.032–3.355, P = 0.039). Neutrophil-to-lymphocyte ratio levels were independently associated with
the occurrence of PSE in the poor functional outcome group, while this association
was not significant in the favorable functional outcome group. The model (cortical
involvement + hematoma volume + early seizures + NLR) showed good prognostic performance.
Conclusion
High NLR at admission is associated with an increased risk of PSE, which suggests
that NLR may play a role in risk stratification in patients with ICH.
Keywords
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Article info
Publication history
Published online: March 22, 2023
Accepted:
March 9,
2023
Received in revised form:
February 24,
2023
Received:
December 18,
2022
Identification
Copyright
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