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Network alterations in eating epilepsy during resting state and during eating using Magnetoencephalography

Published:November 12, 2022DOI:https://doi.org/10.1016/j.yebeh.2022.108946

      Highlights

      • Patients with eating epilepsy show a disrupted network during resting state. During eating, they tend towards a hyperconnected state with deviations from small worldness.
      • Patients with spontaneous seizures show a deviation from small worldness even in a resting state compared to those with pure reflex seizures.
      • Connectivity changes in resting state networks [Default Mode Network, Attention network, sensorimotor networks] were observed in resting state records of patients with eating epilepsy compared to controls.
      • Connectivity changes during eating involved the default mode network nodes, limbic cortex, and nodes participating in the physiological process of eating.

      Abstract

      Objective

      Eating epilepsy presents various imaging and electrophysiological features along with various seizure triggers. As such, network changes in eating epilepsy have not been comprehensively explored. This study was conducted to illustrate resting state network changes in eating epilepsy and to study the changes in network configurations during eating.

      Methods

      Magnetoencephalography recordings of nineteen patients with drug-resistant eating epilepsy were compared with healthy controls during resting state. A subgroup of nine patients and 12 controls had MEG recordings during eating. Network changes were analyzed using phase lag index across 5 frequency bands [delta, theta, alpha, beta, and gamma] using clustering coefficient (CC), betweenness centrality (BC), path length (PL), modularity (Q), and small worldness (SW).

      Results

      During the resting state, PL was decreased in patients with epilepsy in the delta, theta, and gamma band. Q was lower in patients with epilepsy in the beta and gamma bands. During eating, in patients with epilepsy, PL and SW were increased in all frequency bands, and Q was decreased in the beta band and increased in the rest of the frequency bands. Patients with mixed types of seizures showed higher PL in all bands except alpha, higher Q in all bands, and higher SW in the alpha and beta bands. Node-wise changes in CC and BC implicated changes in DMN and ‘eating’ networks.

      Conclusion

      Reflex Eating epilepsy presents with a hyperconnected network that exacerbates during eating. The cause of seizure onset and loss of consciousness in eating epilepsy might be due to aberrant network interaction between the regions of the brain involved with eating, such as the sensorimotor cortex, lateral parietal cortex, and insula with the limbic cortex and default mode network across multiple frequency bands.

      Keywords

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