Highlights
- •Relation between coffee consumption and seizure frequency might depend on dose.
- •There was no relation between coffee consumption and total seizure frequency.
- •The number of FBTCS was significantly associated with usual coffee consumption.
- •Moderate coffee consumption was associated with lower risk of FBTCS.
- •These results need to be confirmed in a dedicated prospective study.
Abstract
Objective
To assess the relation between coffee consumption and seizure frequency in patients
with drug-resistant focal epilepsy.
Methods
Cross-sectional analysis of data collected in the SAVE study, which included patients
with drug-resistant focal epilepsy during long-term EEG monitoring. Patients in whom
both coffee consumption and data about seizure frequency, including focal to bilateral
tonic-clonic seizures (FBTCS), were available were selected. Coffee consumption was
collected using a standardized self-report questionnaire and classified into four
groups: none, rare (from less than 1 cup/week to up 3 cups/week), moderate (from 4
cups/week to 3 cups/day), and high (more than 4 cups/day).
Results
Six hundred and nineteen patients were included. There was no relation between coffee
consumption and total seizure frequency (p = 0.902). In contrast, the number of FBTCS reported over the past year was significantly
associated with usual coffee consumption (p = 0.029). Specifically, number of FBCTS in patients who reported moderate coffee
consumption was lower than in others. In comparison with patients with moderate coffee
consumption, the odds ratio (95%CI) for reporting at least 1 FBTCS per year was 1.6
(1.03–2.49) in patients who never take coffee, 1.62 (1.02–2.57) in those with rare
consumption and 2.05 (1.24–3.4) in those with high consumption. Multiple ordinal logistic
regression showed a trend toward an association between coffee consumption and number
of FBTCS (p = 0.08).
Conclusions and relevance
Our data suggest that effect of coffee consumption on seizures might depend on dose
with potential benefits on FBTCS frequency at moderate doses. These results will have
to be confirmed by prospective studies.
Keywords
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Article info
Publication history
Published online: December 17, 2021
Accepted:
November 29,
2021
Received in revised form:
November 28,
2021
Received:
October 21,
2021
Identification
Copyright
© 2021 Elsevier Inc. All rights reserved.
