Highlights
- •Cognitive dysfunction in MTLE was a brain network disorder.
- •Changed FC between RSNs may potentially reflect the successful treatment.
- •Unchanged FC after ATL was closely associated with cognitive performance.
Abstract
The aims of this study were to investigate the brain network connectivity alterations
of intractable unilateral mesial temporal lobe epilepsy (MTLE) with cognitive dysfunction
before and after anterior temporal lobectomy (ATL) using resting-state functional
magnetic resonance imaging (rs-fMRI) study and to further observe the correlation
between the brain network connectivity with cognitive performance. Fourteen patients
with unilateral left MTLE before and after ATL were compared with thirty healthy controls
(HCs) on functional connectivity (FC) between resting-state networks (RSNs). The correlation
between the neuropsychological tests of patients and abnormal FC was further investigated.
When compared with the HCs, patients before surgery showed significantly changed FC
between special RSNs. No difference of FC was found between each RSN when patients
were compared with the HCs after surgery. Compared with patients before surgery, patients
after surgery showed significantly decreased FC between RSNs. Abnormal FC between
RSNs significantly correlated with Montreal Cognitive Assessment (MoCA) scores. Our
study suggested that dynamic alterations of RSN after ATL in unilateral MTLE may be
closely related with seizure generating. However, unchanged FC between RSN before
and after ATL may be closely related with cognitive performance. The present findings
may help us understand the feature of brain network alterations in patients with left
MTLE who became seizure-free following ATL.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Epilepsy & BehaviorAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Comorbidities of epilepsy: current concepts and future perspectives.Lancet Neurol. 2016; 15: 106-115
- Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan.Lancet. 2012; 380: 1180-1192
- Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures.Brain. 2009; 132: 999-1012
- The neurobiology of cognitive disorders in temporal lobe epilepsy.Nat Rev Neurol. 2011; 7: 154-164
- Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research.Epilepsy Res. 1995; 22: 65-95
- Treatment of epilepsy in adults.Epileptic Disord. 2016; 18: 228-239
- A feasibility trial of an Internet-delivered and transdiagnostic cognitive behavioral therapy treatment program for anxiety, depression, and disability among adults with epilepsy.Epilepsia. 2016; 57: 1887-1896
- Long-term outcomes of surgical treatment for epilepsy in adults with regard to seizures, antiepileptic drug treatment and employment.Seizure. 2017; 44: 217-224
- Introduction to temporal lobe epilepsy.Epilepsy Res. 1996; 26: 141-150
- Resective epilepsy surgery for drug-resistant focal epilepsy: a review.JAMA. 2015; 313: 285-293
- Epilepsy surgery in children and adults.Lancet Neurol. 2014; 13: 1114-1126
- Surgery for epilepsy.Cochrane Database Syst Rev. 2015; (Cd010541): 1-228
- Continuous positive airway pressure therapy for obstructive sleep apnea reduces interictal epileptiform discharges in adults with epilepsy.Epilepsy Behav. 2014; 37: 171-174
- Interactive virtual feedback improves gait motor imagery after spinal cord injury: an exploratory study.Restor Neurol Neurosci. 2016; 34: 227-235
- Ketogenic dietary therapies for adults with epilepsy: feasibility and classification of response.Epilepsy Behav. 2014; 37: 77-81
- Autistic characteristics in adults with epilepsy and perceived seizure activity.Epilepsy Behav. 2015; 52: 244-250
- Resting state functional connectivity of the hippocampus associated with neurocognitive function in left temporal lobe epilepsy.Hum Brain Mapp. 2014; 35: 735-744
- Functional connectivity and language impairment in cryptogenic localization-related epilepsy.Neurology. 2010; 75: 395-402
- Abnormal amplitude low-frequency oscillations in medication-naive, first-episode patients with major depressive disorder: a resting-state fMRI study.J Affect Disord. 2013; 146: 401-406
- Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy.Brain. 2011; 134: 2912-2928
- Default mode network alterations during language task performance in children with benign epilepsy with centrotemporal spikes (BECTS).Epilepsy Behav. 2014; 33: 12-17
- Similarity in functional brain architecture between rest and specific task modes: a model of genetic and environmental contributions to episodic memory.Neuroimage. 2018; 179: 489-504
- Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: a resting-state fMRI study.Prog Neuropsychopharmacol Biol Psychiatry. 2012; 37: 153-160
- Early and late onset, first-episode, treatment-naive depression: same clinical symptoms, different regional neural activities.J Affect Disord. 2012; 143: 56-63
- Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic–clonic seizure.Hum Brain Mapp. 2017; 38: 957-973
- Altered intrinsic functional connectivity of the salience network in childhood absence epilepsy.J Neurol Sci. 2014; 339: 189-195
- Large-scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy.Hum Brain Mapp. 2016; 37: 3137-3152
- Impaired development of intrinsic connectivity networks in children with medically intractable localization-related epilepsy.Hum Brain Mapp. 2014; 35: 5686-5700
- Characteristics of resting-state functional connectivity in intractable unilateral temporal lobe epilepsy patients with impaired executive control function.Front Hum Neurosci. 2017; 11: 609
- Imaging of cerebral venous thrombosis: current techniques, spectrum of findings, and diagnostic pitfalls.Radiographics. 2006; 26 ([discussion S42–3]): S19-S41
- Cerebral venous thrombosis.Presse Med. 2016; 45: e429-e450
- Imaging of cerebral venous thrombosis.Diagn Interv Imaging. 2014; 95: 1145-1150
- DPABI: Data Processing & Analysis for (Resting-State) Brain Imaging.Neuroinformatics. 2016; 14: 339-351
- A comprehensive assessment of regional variation in the impact of head micromovements on functional connectomics.Neuroimage. 2013; 76: 183-201
- The neural network of motor imagery: an ALE meta-analysis.Neurosci Biobehav Rev. 2013; 37: 930-949
- Neural basis of global resting-state fMRI activity.Proc Natl Acad Sci U S A. 2010; 107: 10238-10243
- Anticorrelations in resting state networks without global signal regression.Neuroimage. 2012; 59: 1420-1428
- Trouble at rest: how correlation patterns and group differences become distorted after global signal regression.Brain Connect. 2012; 2: 25-32
- Impact of neurologic deficits on motor imagery: a systematic review of clinical evaluations.Neuropsychol Rev. 2014; 24: 116-147
- Altered functional organization within and between resting-state networks in chronic subcortical infarction.J Cereb Blood Flow Metab. 2014; 34: 597-605
- Aberrant functional organization within and between resting-state networks in AD.PLoS One. 2013; 8e63727
- Dissociable intrinsic connectivity networks for salience processing and executive control.J Neurosci. 2007; 27: 2349-2356
- Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons.Proc Natl Acad Sci U S A. 2016; 113: E8463-e8471
- Multivariate classification of social anxiety disorder using whole brain functional connectivity.Brain Struct Funct. 2015; 220: 101-115
- Cognitive impairment in older adults with epilepsy: characterization and risk factor analysis.Epilepsy Behav. 2016; 56: 113-117
- Long-term outcomes in epilepsy surgery: antiepileptic drugs, mortality, cognitive and psychosocial aspects.Brain. 2007; 130: 334-345
- Perception and use of complementary and alternative medicine among children and adults with epilepsy: the importance of the decision makers.Acta Med Iran. 2014; 52: 153-157
- Epilepsy transition: challenges of caring for adults with childhood-onset seizures.Epilepsia. 2014; 55: 1659-1666
- What does the U.S. Medicare administrative claims database tell us about initial antiepileptic drug treatment for older adults with new-onset epilepsy?.Epilepsia. 2017; 58: 548-557
- Motor system hyperconnectivity in juvenile myoclonic epilepsy: a cognitive functional magnetic resonance imaging study.Brain. 2011; 134: 1710-1719
- Carotid arterial wall MRI at 3T using 3D variable-flip-angle turbo spin-echo (TSE) with flow-sensitive dephasing (FSD).J Magn Reson Imaging. 2010; 31: 645-654
- Early detection and quantification of cerebral venous thrombosis by magnetic resonance black-blood thrombus imaging.Stroke. 2016; 47: 404-409
- Dietary treatment in adults with refractory epilepsy: a review.Neurology. 2014; 83: 1978-1985
- Correspondence of the brain's functional architecture during activation and rest.Proc Natl Acad Sci U S A. 2009; 106: 13040-13045
- Double dissociation of two cognitive control networks in patients with focal brain lesions.Proc Natl Acad Sci U S A. 2010; 107: 12017-12022
- Collateral brain damage, a potential source of cognitive impairment after selective surgery for control of mesial temporal lobe epilepsy.J Neurol Neurosurg Psychiatry. 2004; 75: 323-326
- Cognitive outcomes in patients with chronic temporal lobe epilepsy.Epilepsia. 2006; 47: 96-98
- Regional neocortical thinning in mesial temporal lobe epilepsy.Epilepsia. 2008; 49: 794-803
- Aggressive intracranial and extra-cranial epithelioid hemangioendothelioma: a case report and review of the literature.Neuropathology. 2006; 26: 201-205
- Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.Magn Reson Med. 1995; 34: 537-541
- Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy.Ann Neurol. 2003; 54: 425-432
- Relationship of age at onset, chronologic age, and adequacy of preoperative performance to verbal memory change after anterior temporal lobectomy.Epilepsia. 1995; 36: 137-145
- Postictal psychosis in temporal lobe epilepsy: risk factors and postsurgical outcome?.Epilepsy Res. 2013; 106: 264-272
- Neural mechanisms of autonomic, affective, and cognitive integration.J Comp Neurol. 2005; 493: 154-166
- Investigation of the cingulate cortex in idiopathic generalized epilepsy.Epilepsia. 2015; 56: 1803-1811
- Cortical and white matter alterations in patients with neuropathic pain after spinal cord injury.Brain Res. 2013; 1540: 64-73
- Epilepsy: new advances.Lancet. 2015; 385: 884-898
- Improved black-blood imaging using DANTE-SPACE for simultaneous carotid and intracranial vessel wall evaluation.Magn Reson Med. 2016; 75: 2286-2294
- Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease.Neurology. 2009; 73: 1738-1745
- The MoCA: well-suited screen for cognitive impairment in Parkinson disease.Neurology. 2010; 75: 1717-1725
- Charting the effects of TMS with fMRI: modulation of cortical recruitment within the distributed network supporting semantic control.Neuropsychologia. 2016; 93: 40-52
- Altered structural connectome in temporal lobe epilepsy.Radiology. 2014; 270: 842-848
- Structural substrates for resting network disruption in temporal lobe epilepsy.Brain. 2012; 135: 2350-2357
- Structural connectivity changes in temporal lobe epilepsy: spatial features contribute more than topological measures.Neuroimage Clin. 2015; 8: 322-328
- A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsy.Epilepsia. 2007; 48: 1283-1291
- An integrative theory of prefrontal cortex function.Annu Rev Neurosci. 2001; 24: 167-202
- Executive control function: a review of its promise and challenges for clinical research. A report from the Committee on Research of the American Neuropsychiatric Association.J Neuropsychiatry Clin Neurosci. 2002; 14: 377-405
- Emotional and motivational functions of the prefrontal cortex.Brain Nerve. 2016; 68: 1291-1299
- Brain imaging of the central executive component of working memory.Neurosci Biobehav Rev. 2002; 26: 105-125
- The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: a latent variable analysis.Cogn Psychol. 2000; 41: 49-100
- Is working memory still working?.Am Psychol. 2001; 56: 851-864
- Linking DMN connectivity to episodic memory capacity: what can we learn from patients with medial temporal lobe damage?.Neuroimage Clin. 2014; 5: 188-196
- Voxel-based morphometry of temporal lobe epilepsy: an introduction and review of the literature.Epilepsia. 2008; 49: 741-757
- Altered intrinsic functional coupling between core neurocognitive networks in Parkinson's disease.Neuroimage Clin. 2015; 7: 449-455
- Neural dynamics underlying varying attentional control facing invariant cognitive task upon invariant stimuli.Neuroscience. 2017; 353: 133-146
- The significance of the default mode network (DMN) in neurological and neuropsychiatric disorders: a review.Yale J Biol Med. 2016; 89: 49-57
- Electrophysiological signatures of resting state networks in the human brain.Proc Natl Acad Sci U S A. 2007; 104: 13170-13175
- Meditation experience is associated with differences in default mode network activity and connectivity.Proc Natl Acad Sci U S A. 2011; 108: 20254-20259
- Recruitment of the default mode network during a demanding act of executive control.. 2015; 4e06481
- Default mode network in the effects of delta9-tetrahydrocannabinol (THC) on human executive function.PLoS One. 2013; 8e70074
- Quantitative MRI of the prefrontal cortex and executive function in patients with temporal lobe epilepsy.Epilepsy Behav. 2009; 15: 186-195
- Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy.Neurology. 2006; 67: 1674-1676
- Decreased functional connectivity in an executive control network is related to impaired executive function in Internet gaming disorder.Prog Neuropsychopharmacol Biol Psychiatry. 2015; 57: 76-85
- Predicting human resting-state functional connectivity from structural connectivity.Proc Natl Acad Sci U S A. 2009; 106: 2035-2040
Article info
Publication history
Published online: August 13, 2018
Accepted:
July 21,
2018
Received in revised form:
July 1,
2018
Received:
June 21,
2018
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
