Cannabis and epilepsy

Published:February 18, 2017DOI:
      A treatise, written in the 15th century by Ibn al-Badri, preserved as a manuscript in Paris, tells that the poet Ali ben Makki gave hashish to Zahir-ad-din Mihammed, the epileptic son of the Chamberlain of the Caliphate Council in Baghdad. Zahir had no more seizures, but had to stay on the drug ever after [
      • Rosenthal F.
      The herb hashish versus medieval Muslim society.
      ]. Actually, cannabis, in many of its forms, was previously used for centuries against seizures in India and possibly in China.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Epilepsy & Behavior
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Rosenthal F.
        The herb hashish versus medieval Muslim society.
        E. J. Brill, Leiden1971
        • Mechoulam R.
        • Shvo Y.
        The structure of cannabidiol.
        Tetrahedron. 1963; 19: 2073-2078
        • Cunha J.M.
        • Carlini E.A.
        • Pereira A.E.
        • Ramos O.L.
        • Pimentel G.
        • Gagliardi R.
        • et al.
        Chronic administration of CBD to healthy volunteers and epileptic patients.
        Pharmacologia. 1980; 21: 175-185
        • Devinsky O.
        • Marsh E.
        • Friedman D.
        • Thiele E.
        • Laux L.
        • Sullivan J.
        • et al.
        Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.
        Lancet Neurol. 2016; 15: 270-278
        • Tzadok M.
        • Uliel-Siboni S.
        • Linder I.
        • Kramer U.
        • Epstein O.
        • Menascu S.
        • et al.
        CBD-enriched medical cannabis for intractable pediatric epilepsy: the current Israeli experience.
        Seizure. 2016; 35: 41-44
        • Pucci M.
        • Rapino C.
        • Di Francesco A.
        • Dainese E.
        • D'Addario C.
        • Maccarrone M.
        Epigenetic control of skin differentiation genes by phytocannabinoids.
        Br J Pharmacol. 2013; 170: 581-591