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A “triple threat” career in epilepsy surgery

Published:January 13, 2016DOI:https://doi.org/10.1016/j.yebeh.2015.11.030
      When I was an adolescent, as adolescents will, I mused about my career, deciding that I wanted to help people with disease and also discover new knowledge. I had wanted to be a physician since I was very young, although I do not know why, for no immediate relatives were physicians, and my only contacts with doctors had been routine visits. Since my older brother also became a physician, there was probably some covert family influence. Yet looking back on my career now at the end of my eighth decade, those adolescent musings pretty well describe much of it. My interest in the brain is more readily explained: an influence of my father, a professor of child psychology and parent education (despite my brother's and my view that there was a large gap between theory and practice), and in medical school at the University of Iowa by an excellent neuroanatomy course of Dr. W. R. Ingram, and neurology clerkship under Dr. Adolph Sahs, augmented by a summer rotation on the neurology service of the Massachusetts General Hospital with Drs. Raymond Adams and C. Miller Fisher. Up to this point, I had received an excellent clinical exposure to neurology, but very little to neurosurgery, and essentially none to research, nor had I any special interest in epilepsy.
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      References

      1. Purpura D.P. Penry J.K. Walters R.D. Advances in neurology, appendix. Raven Press, New York1975
        • Ojemann G.A.
        • Fedio P.
        • Van Buren J.M.
        Anomia from pulvinar and subcortical parietal stimulation.
        Brain. 1968; 91: 99-116
        • Ojemann G.A.
        • Hebb A.O.
        The thalamus and language revisited.
        Brain Lang. 2013; 126: 99-108
        • Haglund M.M.
        Ojemann L.M. Seizure outcomes in patients undergoing temporal lobe resections for epilepsy. In: Silbergeld D, Ojemann GA, editors.
        Epilepsy surgery Neurosurg Clin N Am. 1993; 4: 337-344
        • Batzel L.W.
        • Fraser R.T.
        Resection surgery for epilepsy: outcome and quality of life. In: Silbergeld D, Ojemann GA, editors. Epilepsy surgery.
        Neurosurg Clin N Am. 1993; 4: 345-351
      2. Engel Jr., J. Surgical treatment of the epilepsies. Raven Press, New York1987
        • Ojemann G.A.
        Surgical therapy for medically intractable epilepsy.
        J Neurosurg. 1987; 66: 489-499
        • Penfield W.
        • Roberts L.
        Speech and brain-mechanisms.
        Princeton University Press, 1959
        • Ojemann G.
        • Ojemann J.
        • Lettich E.
        • Berger M.
        Cortical language localization in left, dominant hemisphere: an electrical stimulation mapping investigation in 117 patients.
        J Neurosurg. 1989; 71: 316-326
        • Ojemann G.
        Electrical stimulation and neurobiology of language.
        Behav Brain Sci. 1983; 6: 221-230
        • Haglund M.M.
        • Berger M.S.
        • Shamseldin M.S.
        • Lettich E.
        • Ojemann G.A.
        Cortical localization of temporal lobe language sites in patients with gliomas.
        Neurosurgery. 1994; 34: 567-576
        • Giussani C.
        • Roux F.E.
        • Ojemann J.G.
        • Sganzerla E.P.
        • Pirillo D.
        • Papagnos C.
        Is preoperative functional magnetic resonance imaging reliable for language area mapping in brain tumor surgery? Review of language functional imaging and direct cortical stimulation studies.
        Neurosurgery. 2010; 66: 113-120
        • Ojemann S.
        • Berger M.
        • Lettich E.
        • Ojemann G.
        Localization of language function in children: results of electrical stimulation mapping.
        J Neurosurg. 2003; 98: 465-470
        • Lucas II, T.H.
        • Drane D.L.
        • Dodrill C.B.
        • Ojemann G.A.
        Language reorganization in aphasics: an electrical stimulation mapping investigation.
        Neurosurgery. 2008; 63 ([discussion 497]): 487-497
        • Ojemann G.A.
        • Whitaker H.A.
        The bilingual brain.
        Arch Neurol. 1978; 35: 409-412
        • Lucas II, T.H.
        • McKhann II, G.M.
        • Ojemann G.A.
        Functional separation of languages in the bilingual brain: a comparison of electrical stimulation language mapping in 25 bilingual patients and 117 monolingual control patients.
        J Neurosurg. 2004; 101: 449-457
        • Mateer C.A.
        • Polen S.B.
        • Ojemann G.A.
        • Wyler A.R.
        Cortical localization of finger spelling and oral language: a case study.
        Brain Lang. 1982; 17: 46-57
        • Haglund M.M.
        • Ojemann G.A.
        • Lettich E.
        • Bellugi U.
        • Corina D.
        Dissociation of cortical and single unit activity in spoken and signed languages.
        Brain Lang. 1993; 44: 19-27
        • Corina D.
        • McBurney S.
        • Dodrill C.
        • Hinshaw K.
        • Brinkley J.
        • Ojemann G.
        Functional roles of Broca's area and SMG: evidence from cortical stimulation mapping in a deaf signer.
        Neuroimage. 1999; 10: 570-581
        • Ojemann G.A.
        Some brain mechanisms for reading.
        in: Von Euler C. Lundberg I. Lennerstrand G. Brain and reading. MacMillan Press Ltd, Hampshire1989: 47-59
        • Ojemann J.
        • Ojemann G.
        • Lettich E.
        Cortical stimulation mapping of language cortex by using a verb generation task: effects of learning and comparison to mapping based on object naming.
        J Neurosurg. 2002; 97: 33-38
        • Corina D.
        • Gibson E.
        • Martin R.
        • Poliakov A.
        • Brinkley J.
        • Ojemann G.A.
        Dissociation of action and object naming: evidence from cortical stimulation mapping.
        Hum Brain Mapp. 2005; 24: 1-10
        • Ojemann G.A.
        Organization of short-term verbal memory in language areas of human cortex: evidence from electrical stimulation.
        Brain Lang. 1978; 5: 331-340
        • Ojemann G.A.
        • Dodrill C.B.
        Verbal memory deficits after left temporal lobectomy for epilepsy: mechanism and intraoperative prediction.
        J Neurosurg. 1985; 62: 101-107
        • Ojemann G.A.
        • Mateer C.
        Human language cortex: localization of memory, syntax and sequential motor-phoneme identification systems.
        Science. 1979; 205: 1401-1403
        • Ojemann G.A.
        • Mateer C.
        Cortical and subcortical organization of human communications: evidence from stimulation studies.
        in: Steklis H. Raleigh M. Neurobiology of social communications in primates. Academic Press, New York1979: 111-131
        • Fried I.
        • Mateer C.
        • Ojemann G.
        • Wohns R.
        • Fedio P.
        Organization of visuospatial functions in human cortex: evidence from electrical stimulation.
        Brain. 1982; 105: 349-371
        • Ojemann G.A.
        • Dodrill C.B.
        Intraoperative techniques for reducing language and memory deficits with left temporal lobectomy.
        Adv Epileptology. 1987; 16: 327-330
        • McKhann II, G.M.
        • Schoenfield-McNeill J.
        • Born D.E.
        • Ojeman G.A.
        Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery.
        J Neurosurg. 2000; 93: 44-52
        • Fried I.
        • Ojemann G.A.
        • Fetz E.E.
        Language-related potentials specific to human language cortex.
        Science. 1981; 212: 353-356
        • Ojemann G.A.
        • Fried I.
        • Lettich E.
        Electrocorticographic (ECoG) correlates of language. I. Desynchronization in temporal language cortex during object naming.
        EEG Clin Neurophysiol. 1989; 73: 453-463
        • Ward Jr., A.A.
        • Thomas L.B.
        The electrical activity of single units in the cerebral cortex of man.
        EEG Clin Neurophysiol. 1955; 7: 135-136
        • Ward Jr., A.A.
        • Schmidt R.F.
        Some properties of single epileptic neurons.
        Arch Neurol. 1961; 5: 308-313
        • Calvin W.H.
        • Ojemann G.A.
        • Ward Jr., A.A.
        Human cortical neurons in epileptogenic foci: comparison of interictal firing patterns to those of “epileptic” neurons in animals.
        EEG Clin Neurophysiol. 1973; 34: 337-351
        • Wyler A.R.
        • Ojemann G.A.
        • Ward Jr., A.A.
        Neurons in human epileptic cortex: correlation between unit and EEG activity.
        Ann Neurol. 1982; 11: 301-308
        • Moseley J.
        • Ojemann G.A.
        • Ward Jr., A.A.
        Unit activity in experimental epileptic foci during focal cortical hypothermia.
        Exp Neurol. 1972; 37: 164-178
        • Reynolds Jr., A.F.
        • Ojemann G.A.
        • Ward Jr., A.A.
        Intracellular recording during focal hypothermia in cat pericruciate cortex.
        Exp Neurol. 1975; 46: 556-582
        • Reynolds Jr., A.F.
        • Ojemann G.A.
        • Ward Jr., A.A.
        Intracellular recording during focal hypothermia of penicillin and alumina experimental epileptic foci.
        Exp Neurol. 1975; 46: 583-604
        • Kusske J.
        • Ojemann G.A.
        • Ward Jr., A.A.
        Effects of lesions in ventral anterior thalamus on experimental focal epilepsy.
        Exp Neurol. 1972; 34: 279-290
        • Ojemann G.A.
        Basic mechanisms implicated in surgical treatments of epilepsy.
        in: Ward Jr., A.A. Lockard J. Epilepsy: A window to brain mechanisms. Raven Press, 1980: 261-277
        • Oakley J.
        • Ojemann G.
        Effects of chronic stimulation of the caudate nucleus on a preexisting alumina seizure focus.
        Exp Neurol. 1982; 75: 360-367
        • Ojemann G.A.
        Human temporal cortical single neuron activity during language: a review.
        Brain Sci. 2013; 3: 627-641https://doi.org/10.3390/brainsci3020627
        • Ojemann G.A.
        Human lateral temporal cortical single neuron activity during language, recent memory and learning.
        in: Fried I. Rutishauser U. Cerf M. Kreiman G. Single neuron studies of the human brain: Probing cognition. MIT Press, 2014: 247-272
        • Ojemann G.A.
        • Schoenfield-McNeil J.
        Neurons in human temporal cortex active with verbal associative learning.
        Brain Lang. 1998; 64: 317-327
        • Lucas T.H.
        • Schoenfield-McNeill J.
        • Weber P.B.
        • Ojemann G.A.
        A direct measure of human lateral temporal lobe neurons responsive to face matching.
        Cogn Brain Res. 2003; 18: 15-25
        • Calvin W.H.
        • Ojemann G.A.
        Inside the brain.
        New American Library, New York1980
        • Calvin W.H.
        • Ojemann G.A.
        Conversation with Neil's brain.
        Addison-Wesley, New York1995 ([Paperback, German, Dutch editions])