We have been studying the role of hyperpolarization-activated (HCN) ion channels in
epilepsy and the mechanisms underlying their chronic downregulation. We published
findings (Jung et al., J. Neurosci., 2010) that downregulation of HCN channel gating in chronic epilepsy was associated
in part with decreased activity of p38 mitogen-activated kinase (p38 MAPK). Although
this phosphorylation pathway affects numerous cellular processes, we asked whether
pharmacological reversal of the p38 MAPK activation deficit in vivo might produce
an antiepileptic benefit in chronically epileptic animals.
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Article info
Publication history
Accepted:
February 17,
2015
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Copyright
© 2015 Published by Elsevier Inc.
