Abstract| Volume 38, P218, September 2014

084 — (VIA0027) Involvement of the GABAergic system in the anxiolytic-like effect of the Citrus limon essential oil in mice

      Rationale: The current treatments for anxiety disorders have multiple adverse effects in addition to a delayed onset of action, which has prompted efforts to find new substances with potential activity in this disorder. Citrus limon was chosen based on ethnopharmacological data since traditional medicine refers to the Citrus genus as useful in diminishing the symptoms of anxiety or insomnia. In a previous study, we demonstrated that the essential oil (EO) of C. limon presents an anxiolytic effect in murine models. In this regard, the aim of this study was to evaluate the involvement of GABAergic and dopaminergic pathways in the mechanism of anxiolytic action of the oil from the fruit peels of lemon in mice.
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