Rationale: The current treatments for anxiety disorders have multiple adverse effects in addition
to a delayed onset of action, which has prompted efforts to find new substances with
potential activity in this disorder. Citrus limon was chosen based on ethnopharmacological data since traditional medicine refers to
the Citrus genus as useful in diminishing the symptoms of anxiety or insomnia. In a previous
study, we demonstrated that the essential oil (EO) of C. limon presents an anxiolytic effect in murine models. In this regard, the aim of this study
was to evaluate the involvement of GABAergic and dopaminergic pathways in the mechanism
of anxiolytic action of the oil from the fruit peels of lemon in mice.
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© 2014 Published by Elsevier Inc.
