Rationale: The current treatments for anxiety disorders have multiple adverse effects in addition to a delayed onset of action, which has prompted efforts to find new substances with potential activity in this disorder. Citrus limon was chosen based on ethnopharmacological data since traditional medicine refers to the Citrus genus as useful in diminishing the symptoms of anxiety or insomnia. In a previous study, we demonstrated that the essential oil (EO) of C. limon presents an anxiolytic effect in murine models. In this regard, the aim of this study was to evaluate the involvement of GABAergic and dopaminergic pathways in the mechanism of anxiolytic action of the oil from the fruit peels of lemon in mice.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Epilepsy & Behavior
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
© 2014 Published by Elsevier Inc.