- •Fixed human brains display frequency-specific current response.
- •Right hippocampus displayed increased gamma power to any frequency.
- •Right parahippocampal region responded exclusively to 7-Hz spikes.
- •Right parahippocampal region shows 7-Hz and 40-Hz response indicators.
If structure dictates function within the living human brain, then the persistence of specific responses to weak electric currents in fixed, deceased brains could reflect “hardwired” properties. Different key structures from the left and right hemispheres of brains that had been fixed for over 20 years with ethanol–formalin–acetic acid were stimulated with either 1-Hz, 7-Hz, 10-Hz, 20-Hz, or 30-Hz, sine-wave, square-wave, or pulsed currents while needle-recorded quantitative electroencephalographic responses were obtained. Differential responses occurred only within the right hippocampus and parahippocampal gyrus. The right hippocampus displayed frequency-independent increases in gamma power relative to the left hemispheric homologue. The parahippocampal region responded exclusively to 7-Hz pulsed currents with wideband (8–30 Hz) power. These profiles are consistent with dynamic connections associated with memory and consciousness and may partially explain the interactions resultant of pulse type and hemisphere for experiential elicitations during the golden age of surgical stimulations. The results also indicate that there may be an essential “hardwiring” within the human brain that is maintained for decades when it is fixed appropriately.
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Published online: May 18, 2016
Accepted: April 12, 2016
Received in revised form: April 11, 2016
Received: February 4, 2016
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